ABSTRACT
Objective To investigate the regulatory effect of poria cocos on gastrointestinal motility in mice. Methods A total of 130 Kunming mice were randomly divided into negative control group, low-dose and high-dose groups of raw poria cocos powder, low-dose and high-dose groups of cooked poria cocos powder, low-dose and high-dose groups of poria cocos surrogate culture powder, low-dose, medium-dose and high-dose groups of poria cocos water extract, and low-dose, medium-dose and high-dose groups of poria cocos alcohol extract, with 10 mice in each group. The animals were administered by gavage for 7 days, once a day. After the last administration, the intestinal propulsion function test and gastric solid emptying test were conducted to observe the regulating effect of poria cocos on gastrointestinal motility of mice. Results Compared with the negative control group, the small intestine propulsion rate in the low-dose group of poria cocos surrogate culture powder was significantly increased (P<0.01). Except the high-dose group of raw poria cocos powder, the other poria cocos groups had higher gastric residual rate (P<0.05). Conclusion Poria cocos does not promote intestinal propulsion of mice under normal physiological condition, but it can inhibit gastric empting and exert a moderating effect on gastrointestinal function in normal mice.
ABSTRACT
ATM: To observe the anti-inflammatory, and immunomodulation of Jingchufengshi Ointment (JCFSO) (Semen Strychni, Myrrha Preparata, etc.) on the pathological model. METHODS: Whittle's method, the swelling of rat sole and mice carbon clearance test were used to determine the immunomodulation and anti-inflammatory effect of JCFSO. RESULTS: JCFSO external application could inhibite the swelling of rat sole induced by ameliorates and inhibite the higher permeability of abdominal capillary of rat which was induced by acetic acid and also significantly inhibite the skin delay allergic reaction induced by 2,4-dinitroflurbenzene in rat and reduce immune indices (P